Start Date: 1st June
Award: 1 fully funded 4-year PhD, funded by the Peter Samuel Charitable Trust
Mode of attendance: Full time
Supervisors:
Co-supervisor: Dr Alessio Delogu email: alessio.delogu@kcl.ac.uk
Co-supervisor: Prof. Peter Giese email: karl.giese@kcl.ac.uk
Department: Basic and Clinical Neuroscience
Project description:
The project aims to identify and restore key cellular pathways that are responsible for the early manifestation of Alzheimer’s disease. The goal of the project is to manipulate these pathways in a well-established rodent model of Alzheimer’s disease with a clinically approved compound and monitor changes in disease progression at the molecular, cellular, neuronal network and behavioural levels. The project requires a good academic knowledge of molecular or cellular neuroscience and a genuine interest in understanding the mechanisms of brain disease using in vivo animal models. The PhD candidate will gain advanced skills in biochemical methods, confocal optical microscopy, EEG sleep recording and learning and memory paradigms. This PhD project will be based at the Maurice Wohl Clinical Neuroscience Institute, offering state-of-the-art laboratories, an outstanding Nikon-sponsored microscopy imaging centre (Wohl Cellular Imaging Centre), and on-site animal husbandry facilities. The Maurice Wohl hosts several labs working on mechanistic causes of dementia and is also the site chosen by the Medical Research Council (MRC), Alzheimer’s Society and Alzheimer’s Research UK for one of 7 Dementia Research Institute (DRI-UK) Centres. Numerous events on the topic of dementia research are hosted through the year and provide an intellectually stimulating and supportive environment for the PhD students.
Award type and eligibility
Students will be fully funded for four years full-time, to include home tuition fees, annual stipend and research and travel costs.
International students can apply but must be able to pay the difference in fees (approx. £23,000/year)
To be treated as a Home student, candidates must meet one of the following criteria:
• A UK national (meeting residency requirements)
• Settled status
• Pre-settled status (meeting residency requirements)
• Indefinite leave to remain or enter
Applicants should have (or be expected to obtain) a bachelor’s degree with 2:1 honours (or Overseas equivalent). A 2:2 degree may be considered only where applicants also offer a master’s with Merit.
Applicants must complete and submit an online admissions application, via the admissions portal by midnight (23:59 GMT), 14th of February 2025.
On the ‘Choosing a programme’ page, please select Department of Basic and Clinical Neuroscience Research MPhil/PhD (Full-time).
More information on the department is available at the departmental prospectus page here: https://www.kcl.ac.uk/neuroscience/about/departments/basic-clinical-neuroscience
In your application, you will be asked to include:
In the Funding section, please tick box 5 and include the following reference: ADPG-IoPPN-PSCT25
Please note there is no need to complete the Research Proposal section in your application as the project has already been set.
You are welcome to email Dr Alessio Delogu (email: alessio.delogu@kcl.ac.uk) or Prof. Peter Giese (email: karl.giese@kcl.ac.uk) for more information regarding the project and studentship.
If you have any queries regarding the application process, please contact the Education support team at ioppn.pgr@kcl.ac.uk.
References must be received by the deadline for the applicant to be eligible. Only shortlisted applicants will be contacted.
Closing Date: 14th of February 2025 (23:59 GMT)
Interviews: 6th March 2025
Further information
About the IoPPN (http://www.kcl.ac.uk/ioppn/about/index.aspx)
Studying at the IoPPN (http://www.kcl.ac.uk/ioppn/study/index.aspx)
MSc programmes at the IoPPN (link to https://www.kcl.ac.uk/ioppn/study/postgraduate-taught)
Research degrees at the IoPPN (link to https://www.kcl.ac.uk/ioppn/study/postgraduate-research-programmes)
Home, EU and Overseas Candidates
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